CAUSES OF MESOTHELIOMA
CAUSES OF MESOTHELIOMA
Asbestos exposure is the primary known cause of mesothelioma and is responsible for most cases. Asbestos is made up of tiny fibers that can become airborne and be inhaled or swallowed. Once inside the body, these fibers can remain there for years and may become lodged in the lining of the lungs or other organs, where they can cause inflammation and cellular damage over time.
The connection between asbestos exposure and mesothelioma is extremely strong, although not every person diagnosed with mesothelioma has a clearly documented history of asbestos exposure. In many cases, exposure occurred decades before diagnosis.
Asbestos has been used for centuries, but large-scale commercial use expanded during the 19th and 20th centuries. People who worked in industries such as construction, shipbuilding, manufacturing, mining, insulation work, and certain military occupations faced some of the highest risks of exposure. People who lived near asbestos mines, mills, factories, or other industrial sites may also have been exposed.
Asbestos was widely used in insulation, flooring, roofing, pipe covering, machinery, ships, and many other building and industrial materials, particularly before the 1980s. Because asbestos remains present in many older buildings, ships, equipment, and products, exposure can still occur when these materials are disturbed.
OSHA and the EPA recognize asbestos exposure as a serious health hazard, and there is no known safe level of exposure. In general, the greater a person’s cumulative exposure to asbestos, the greater the risk of developing an asbestos-related disease. However, asbestos exposure affects people differently. Factors such as the amount and duration of exposure, the type of asbestos fibers involved, the way exposure occurred, and individual susceptibility may all influence risk.
This variation helps explain why one person may develop mesothelioma after relatively limited exposure while another person with heavier exposure may never develop an asbestos-related disease. For example, family members have sometimes been exposed through asbestos fibers carried home on a worker’s clothing. A spouse who regularly laundered contaminated work clothes could be exposed even without ever working directly with asbestos.
Most people who are exposed to asbestos do not go on to develop mesothelioma, lung cancer, or asbestosis. However, because mesothelioma can develop decades after exposure, past exposure remains medically important even when it occurred many years earlier.

Published by: Veterans Asbestos Alliance
Reviewer: T. Scott Hames, Asbestos Litigation Attorney
Last reviewed: October 2026
Sources:
• National Cancer Institute, Mesothelioma Causes and Risk Factors
• Centers for Disease Control and Prevention, Mesothelioma Basics
• U.S. Department of Veterans Affairs, Asbestos Exposure
• U.S. Environmental Protection Agency, Learn About Asbestos